Cell Culture Media, Supplements, and Reagents
MSC PRO-SOURCE Replacement Part, Press Line Component, With Link
This product is a PRO-SOURCE replacement component designed for press line applications. It includes a link for straightforward integration into relevant systems.
- Dedicated replacement component.
- Equipped with a link.
- Manufactured in China.
Medchemexpress LLC Isonicotinic acid hydrazide-d4 | 774596-24-6 | 99.9% | 1 MG
Isoniazid-d4 is a deuterium-labeled form of Isoniazid, a proagent activated by the bacterial catalase-peroxidase enzyme KatG. It exhibits bactericidal activity against rapidly dividing mycobacteria and possesses anti-tuberculostatic properties.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC D-Ornithine hydrochloride | 16682-12-5 | 98.0% | 168.62 | 1 ML
D-Ornithine hydrochloride is a key constituent of bacterial cell walls. This compound plays a role in promoting the production of L-arginine and enhancing the expression of pyrrolysine-containing proteins.
- Constituent of bacterial cell wall.
- Promotes production of L-arginine.
- Enhances expression of pyrrolysine-containing proteins.
- Selectively up-regulates L-arginine in tobacco cells.
- Promotes insertion of pyrroline-carboxy-lysine into proteins in E. coli and HEK293 cells.
- Stimulates production of spermidine and spermine in tobacco cells.
Medchemexpress LLC Ampicillin (trihydrate) | 7177-48-2 | 99.9% | 25 G
Ampicillin trihydrate is a broad-spectrum beta-lactam antibiotic effective against various gram-positive and gram-negative bacteria. It is for research use only and not sold to patients.
- Effective against a variety of gram-positive and gram-negative bacteria.
- Inhibits E. coli growth in a dose-dependent manner.
- Alleviates symptoms of hemorrhagic enteritis in pigs.
- Produces high concentrations in bile and portal blood.
- Provides neuroprotection against ischemia-reperfusion brain injury.
Medchemexpress LLC Kanamycin (Kanamycin A) | 59-01-8 | 100.0% | 484.50 | 200 MG
Kanamycin (Kanamycin A) is an orally active antibacterial agent effective against gram-negative and gram-positive bacteria. It inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. It shows good inhibitory activity against both *M. tuberculosis* (sensitive and drug-resistant) and *K. pneumonia*, and can be used in studies of tuberculosis and pneumonia.
- Effective against gram-negative and gram-positive bacteria.
- Inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit.
- Shows good inhibitory activity against *M. tuberculosis* (sensitive and drug-resistant).
- Shows good inhibitory activity against *K. pneumonia*.
- Suitable for studies of tuberculosis and pneumonia.
Medchemexpress LLC Medroxyprogesterone acetate-d3 | 98.1% | 389.54 g/mol | C24H31D3O4 | 10 MG
Medroxyprogesterone acetate-d3 is the deuterated analog of medroxyprogesterone acetate, provided as an analytical internal standard for quantitative LC-MS and related mass spectrometry applications. It offers an isotopic match to the target analyte to improve accuracy and correct for matrix effects during sample preparation and analysis.
- Deuterated internal standard for LC-MS quantitation.
- Purity: 98.13% (typical, verified by HPLC).
- Molecular weight 389.54 g/mol.
- Chemical formula C24H31D3O4.
- Supplied in milligram quantities suitable for analytical use.
- Suitable for standard curve preparation and recovery experiments.
Medchemexpress LLC MK-28 | 864388-65-8 | >99.8% | 396.44 | 50 MG
MK-28 is a potent and selective PERK activator with remarkable pharmacokinetic properties and high BBB penetration in mice. It improves systemic function and survival in R6/2 mice and induces increased levels of eIF2α-P in the mouse brain striatum. It also significantly improves motor and executive functions and delays death onset in R6/2 mice without observed toxicity.
- Demonstrates PERK selectivity on a 391-kinase panel
- Rescues cells from ER stress-induced apoptosis
- Increases ATF4 protein levels significantly, up to 2.5-fold
- Significantly increases CHOP and GADD34 mRNA levels
- Minimal effect on EIF2AK1 (HRI) or EIF2AK2 (PKR)
- Activates EIF2AK4 (GCN2)
- Improves systemic function and survival in R6/2 mice
- Induces increased levels of eIF2α-P in the mouse brain striatum
- Significantly enhances motor and executive functions
- Delays death onset in R6/2 mice with no observed toxicity
Medchemexpress LLC NVP 231 | 362003-83-6 | 99.7% | 431.55 | 500 MG
NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor with an IC50 of 12 nM, which competitively inhibits the binding of ceramide to CerK. It induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage.
- Potent, specific, and reversible CerK inhibitor.
- IC50 of 12 nM for CerK.
- Competitively inhibits ceramide binding to CerK.
- Induces cell apoptosis.
- Reduces cellular CerK activity (IC50: 59.70 ± 12 nM).
- Decreases cell viability dose-dependently.
- Induces caspase-3 and caspase-9 cleavage and activation.
- Upregulates cyclin B1 phosphorylation at Ser133.
- Reduces CDK1 phosphorylation at Tyr15.
- Total CDK1 expression declined.
Medchemexpress LLC BX517 | 850717-64-5 | 98.0% | 282.30 | 100 MG
BX517 is a potent and selective inhibitor of PDK1, demonstrating an IC50 of 6 nM. It effectively blocks the activation of Akt in various tumor cells with submicromolar potency. This compound exhibits significant selectivity, being at least 100-fold more selective against PDK1 compared to a panel of seven other Ser/Thr and Tyr kinases.
- Potent and selective inhibitor of PDK1
- Blocks activation of Akt in tumor cells
- Exhibits submicromolar potency
- Highly selective against other Ser/Thr and Tyr kinases
Medchemexpress LLC Fenbendazole-d3 | 1228182-47-5 | 99.70% | 5 MG
Fenbendazole-d3 is a deuterium-labeled version of Fenbendazole. It acts as a HIF-1α agonist, stimulating the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent known for its broad antiparasitic effects. It functions as a microtubule destabilizing agent, leading to cell-cycle arrest and mitotic cell death, and has also demonstrated antitumor activity in mice xenografted with wild-type p53.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Reverses the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration in BT-549 and MCF-7 cells at 20 μM for 48 h
- Elevates the protein expression levels of HIF-1α and GLUT1 in BT-549 and MCF-7 cells at 10 μM for 48 h
Medchemexpress LLC Lobeline (hydrochloride) | 134-63-4 | 99.9% | 50 MG
Lobeline hydrochloride is a brain-penetrant nicotinic receptor agonist that increases dopamine release by inhibiting dopamine uptake into synaptic vesicles and altering presynaptic dopamine storage. It is effective in smoking cessation and is intended for research use only.
- Brain-penetrant nicotinic receptor agonist
- Increases dopamine release
- Inhibits dopamine uptake into synaptosomes and vesicles
- Effective in smoking cessation studies
- Decreases d-methamphetamine self-administration in rat models